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. 2023 Sep 20;14:5849. doi: 10.1038/s41467-023-41506-0

Fig. 7. Model illustrating potential functions of Polε cycling on and off MCM ring.

Fig. 7

a Polε binding to the MCM ring facilitates its engagement with the PCNA-DNA complex to drive strand extension. b DNA translocating away the Mcm2:5 interface releases Polε from MCM. c Polε flips over CMG helicase to target parental histones via Dpb3-4 for redisposition of epigenetic information from parental DNA strand to newly synthesized leading strand. d Upon DNA damage, a flexible Polε can provide access to other polymerases for damage repair and/or re-priming for fork restart. e Leading-strand DNA relocating to the Mcm2:5 interface enables Polε binding to MCM to re-establish strand extension. f DNA translocation by CMG initiates a new round of Polε cycling on and off the MCM ring.