Table 1.

Baseline disease characteristics (ENR population)

Baseline	All (n = 210)	Naïves (n = 80)	Non-naïves (n = 130)
Age, mean years ± SD [range]	47.0 ± 8.6 [21; 69]	47.8 ± 9.1 [21; 67]	46.5 ± 8.2 [22; 69]
Female (%)	71.4	65.0	75.3
Caucasian (%)	100	100	100
DMT naïve (%)	38.0	100	0
Education, mean years ± SD [range]	12.5 ± 3.6 [5;20]	12.3 ± 3.3 [8; 20]	12.6 ± 3.6 [5; 18]
Time from
• Symptoms onset, mean years (SD)	11.8 (9.9)	6.7 (8.7)	14.9 (9.2)*
• Diagnosis, mean years (SD)	8.4 (8.4)	2.9 (5.8)	11.8 (8.0)*
• Onset of last relapse, median years (IQR)	1.6 (0.8–6.8)	0.8 (0.6–1.4)	5.1 (1.4–9.0)*
EDSS, mean (SD)	1.97 (1.33)	1.76 (1.23)	2.10 (1.37)
No. of relapses in previous year (% of enrolled population with available data)	n = 204	n = 124	n = 80
• 0	60.8	37.5	75.8 *
• 1	35.3	56.2	21.8 *
• ≥ 2	3.9	6.2	2.4 *
No. of relapses in the last 2 years (% of enrolled population with available data)	n = 203	n = 124	n = 79
• 0	48.3	17.7	67.7*
• 1	40.9	65.8	25.0*
• ≥ 2	10.8	16.5	7.3*
Severity of last relapse (%)
• Mild	63.3	62.5	63.8
• Moderate	34.8	36.2	33.8
• Severe	1.9	1.2	2.3
SDMT T-score, mean (SD)	45.1 (13.4)	46.63 (13.67)	44.04 (13.21)
BDI, mean (SD)	6.5 (6.2)	5.89 (5.42)	6.79 (6.54)
FSS, mean (SD)	3.9 (1.8)	3.68 (1.83)	4.01 (1.71)

*p < 0.0001 vs. Naïves