Table 1.

MR estimates of the causal association and compensatory sensitivity analyses between T2DM and osteoporosis and BMD

Exposure	Outcome	Main analysis		Compensatory sensitivity analyses
		MRE-IVW		Weighted median		MR-Egger		MR-Egger regression		Cochran’s Q test
		OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p	Egger_intercept	p	Q value	p
T2DM	Osteoporosis	0.92 (0.86, 0.99)	0.016	0.92 (0.83, 1.03)	0.144	0.89 (0.74, 1.07)	0.221	0.0025	0.729	65.107	0.369
	BMD	1.247 (1.064, 1.463)	6.49 × 10−3	1.425 (1.11, 1.83)	5.50 × 10−3	1.196 (0.762, 1.879)	0.440	0.0034	0.846	56.633	0.563

MR Mendelian randomization, MRE-IVW multiplicative random effects-inverse variance-weighted, OR odds ratio, CI confidence interval, T2DM type 2 diabetes mellitus, BMD bone mineral density