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. 2023 Sep 20;11:49. doi: 10.1038/s41413-023-00286-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Analysis of the gait of 4-, 8-, and 16-month-old male mice with the CatWalk XT. The intensity corresponds to the mean intensity at the maximum paw contact normalized with the mean of the maximum contact paw area, the speed, and the weight of the mouse. At 4 months: n = 8 for each genotype; at 8 months n = 8 for each genotype; at 16 months: n = 14 for the KO, n = 12 for the WT and n = 10 for the UP. The data were plotted as a box plot showing all points. One-way ANOVA was performed when the distribution was Gaussian and Kruskal–Wallis was performed when the distribution was not Gaussian with differences being considered significant at P values <0.05 (*P < 0.05, **P ≤ 0.01, ***P ≤ 0.001)