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. 2023 Sep 6;10:1228955. doi: 10.3389/fsurg.2023.1228955

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© 2023 Cannizzaro, Zaed, Olei, Fernandes, Peschillo, Milani and Cardia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) A preoperative evaluation of an ICA aneurysm with a DSA. (A-2) A postoperative evaluation after clipping of the previous ICA aneurysm. (B) Image obtained with a surgical microscope of the intracranial aneurysm (IA). (B-2) Postoperative image obtained with a surgical microscope of the IA after clipping. (C) Representative examples of H&E staining performed on IA domes directly fixed in formalin. The aneurysm wall is characterized by fibrosis and foam cells. CD68+ foam cells. (D) A preoperative CTA image of a left ICA aneurysm and (D-2) a DSA evaluation of the same aneurysm. (E) Intraoperative view of the IA obtained before clipping and (E-2) obtained after the clipping. (F) Increase of the ECM associated with widespread rarefaction of the muscular component. In the adventitia, there is also lymphocytic inflammatory infiltrate and granulocytes.