Distribution of MIS-C count over time in relation to SARS-CoV-2 variant eras. Centres are showed by longitude starting from east to west, and are indicated by colours and official abbreviations as follows: RP401ped: Great Ormond Street Hospital for Children, London, U.K.; FRBDX: Bordeaux University Hospital, Bordeaux, France; H12O: Hospital Universitario 12 de Octubre, Madrid, Spain; BCH: Boston Children’s Hospital, Boston, U.S.; CHOP: The Children’s Hospital of Philadelphia, Philadelphia, U.S.; PittCHP: University of Pittsburgh Medical Center, Pittsburgh, U.S.; UMICH: University of Michigan, U.S.