Figure 5.

Expression of PCCA protein in the liver and heart

(A) Immunoblot of hepatic and cardiac PCCA protein from untreated Pcca^+/+ (n = 1), Pcca^−/− (n = 1), and Pcca^+/− (n = 1) and AAV44.9-treated Pcca^+/− (n = 1) and Pcca^−/− (n = 3) mice 4 days post treatment. (B) Immunoblot of hepatic and cardiac PCCA protein from untreated Pcca^+/+ (n = 2) and Pcca^−/− (n = 2) and AAV44.9-treated Pcca^−/− mice (n = 3) 30 days post treatment. (C) Quantification of PCCA protein expression relative to untreated Pcca^+/+ mice from the blots depicted in (A) and (B). ∗p < 0.05, ∗∗p < 0.003, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001.