Table 1. Summary of Epidemiological and Linear MR Analyses of Adiposity Measures and All-Cause Mortality.
| All-cause mortalitya | Effect size per SD change in BMI (95% CI)b | Effect size per SD change in FMI (95% CI)b | Effect size per SD change in WHR (95% CI)b |
|---|---|---|---|
| Adjusted | |||
| MR, OR | 1.29 (1.20-1.38) | 1.45 (1.36-1.54) | 1.51 (1.32-1.72) |
| Epidemiological, HR | 1.14 (1.13-1.16) | 1.15 (1.13-1.17) | 1.41 (1.38-1.43) |
| Unadjusted | |||
| MR, OR | 1.29 (1.11-1.50) | 1.47 (1.33-1.62) | 1.40 (1.19-1.65) |
| Epidemiological, HR | 1.17 (1.15-1.18) | 1.06 (1.04-1.08) | 1.52 (1.51-1.54) |
| Males | |||
| MR, OR | 1.38 (1.26-1.51) | 1.57 (1.43-1.74) | 1.89 (1.54-2.32) |
| Epidemiological, HR | 1.16 (1.14-1.18) | 1.23 (1.21-1.26) | 1.43 (1.41-1.46) |
| Females | |||
| MR, OR | 1.18 (1.06-1.30) | 1.32 (1.22-1.44) | 1.20 (1.06-1.30) |
| Epidemiological, HR | 1.13 (1.11-1.15) | 1.14 (1.12-1.16) | 1.37 (1.34-1.40) |
Abbreviations: MR, mendelian randomization; BMI, body mass index; FMI, fat mass index; HR, hazard ratio; OR, odds ratio; WHR, waist-to-hip ratio.
MR analyses had 50 594 participants in the adjusted model with male and female participants combined; 30 031, male-only cohort; and 20 563, female-only cohort. Epidemiological analyses had 387 672 participants in the adjusted model with male and female participants combined; 177 324, male-only cohort; 210 319, female-only cohort.
Effect sizes are ORs for MR analyses and HRs for epidemiological analyses. HRs indicate the association of a 1-SD unit increase in adiposity measure with risk of all-cause mortality. ORs indicate the association of a 1-SD unit increase in genetically determined adiposity measure with risk of all-cause mortality. The adjusted model was used for all sex-specific analyses. All associations had P < .05.