Table 1:
Study characteristics
| Study (Ref) | Country | Study design | Population | Sample size | Intervention(s) | Control | Transfer type | Outcome Measures | |
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Case | Control | ||||||||
| Allahveisi et al., 2020 (16) | Iran | Randomized Clinical trial | Women with repeated failed implantation | 25 | 25 | Intrauterine infusion of 0.5 ml of PRP was performed 48 h before embryo transfer | Intrauterine infusion of 0.5 ml of Ringer serum was done 48 h before embryo transfer | Frozen embryo transfer | The intrauterine infusion of PRP before frozen embryo transfer in infertile women with a history of Failed implantation will not make any significant effect on the result of pregnancy. |
| Zamaniyan et al., 2020 (28) | Iran | Randomized controlled trial | Women with recurrent implantation failure | 55 | 43 | The 0.5 ml of intrauterine infusion of platelet-rich plasma at 4–6 times higher concentration than peripheral blood infused intrauterine 48 h before embryo transfer. | Standard protocol | Frozen embryo transfer | Intrauterine infusion of platelet-rich plasma 48 h before freeze thawed embryo transfer may have more effectiveness in in vitro fertilization (IVF) outcomes in recurrent implantation failure. |
| Zargar et al., 2021 (29) | Iran | Prospective randomized Trial | Infertile women with at least two IVF failures | 40 | 40 | Intrauterine infusion of PRP | Patients without PRP injection | Frozen embryo transfer | Endometrial injection of platelet-rich plasma for IVF failure patients did not significantly improve the IVF process, pregnancy, and live birth rates. |
| Aghajanzadeh et al., 2020 (27) | Iran | Women suffering from repeated implantation failure | 30 | 0 | Intrauterine infusions of autologous purified platelet preparations | Standard protocol | Frozen embryo transfer | Platelet-rich plasma might potentially yield beneficial effects as a safe therapeutic option offered alongside other treatments designed to improve the reproductive outcomes of women with repeated implantation failure. | |
| Frantz et al., 2020 (26) | Iran | Retrospective study | Patients with and without a history of having undergone frozen embryo transfers. | 24 | 0 | Platelet-Rich plasma | Standard protocol | Frozen embryo transfer | PRP improves intrauterine receptivity to embryo implantation, regardless Of whether the endometrium reached the appropriate growth for embryo transfer. |
| Tehraninejadet al., 2020 (25) | Iran | Patients suffering from repeated implantation failure | 42 | 43 | 1 ml of PRP was extracted from 10 cc of whole blood via two rounds of centrifugation and infused 2 days before the embryo transfer | Standard protocol | Frozen embryo transfer | PRP is not an effective adjuvant treatment for in vitro fertilization of patients with repeated implantation failure and normal endometrial thickness undergoing embryo transfer. | |
| Melo et al., 2019 (33) | UK | Non-randomized interventional study | Women with low ovarian reserve undergoing fertility Treatment | 46 | 37 | 3-month course of intracortical injections of autologous platelet-rich plasma (PRP) upon ovarian reserve markers | No Intervention | Frozen embryo transfer | PRP injections are effective and safe to improve markers of low ovarian reserve prior to assisted reproductive technology |
| Eftekhar et al., 2018 (21) | Iran | Randomized Clinical trial | Women with thin endometrium (endometrium thickness < 7 mm) | 40 | 43 | HRT+intrauterine infusion of 0.5 to 1 ml PRP on the 13th day of HRT cycle | HRT without intrauterine infusion of PRP | Frozen embryo transfer | Chemical pregnancy, Clinical pregnancy, Miscarriage, Endometrial thickness |
| Obidniak et al., 2017 (30) | Russia | Randomized Clinical trial | RIF, normal karyotype, absence of uterine factors of infertility, absence of chromosomal abnormalities in previous pregnancy | 45 | 45 | Underwent ET with Intrauterine infusion of 2.0 ml of autologous PRP | Underwent ET without intrauterine administration | Frozen embryo transfer | Implantation Rate, Clinical pregnancy |
| Nazari et al., 2019 (23) | Iran | Randomized Clinical trial | RIF: three or more failures of IVF-ET therapy without poor ovarian reserve | 49 | 48 | Intrauterine infusion of 1 ml of platelet-rich plasma 48 hrs. Before blastocyst transfer | Underwent ET without intrauterine administration | Frozen embryo transfer | Chemical pregnancy, Clinical pregnancy |
| Madhavan, et al., 2015 (31) | India | Cohort | RIF: two or more failures of IVF-ET therapy without poor ovarian reserve | 42 | 56 | Patients who received intrauterine infusion of 0.3–0.4 ml PRP on Day 8/9 of the HRT | Underwent ET without intrauterine administration | Frozen embryo transfer | Clinical Pregnancy |
| Chang et al., 2019 (34) | China | Cohort | Patients with thin endometrium | 34 | 30 | HRT+intrauterine infusion of 0.5 to 1 ml PRP on the 13th day of HRT cycle | Underwent ET Without intrauterine administration | Frozen embryo transfer | Implantation Rate, Clinical pregnancy, Miscarriage, Endometrial thickness |
| Mehrafza et al., 2019 (22) | Iran | Cohort | Patients with history of more than 2 repeated failed embryo transfer cycles | 67 | 56 | Intrauterine infusion of 1 ml of PRP | Underwent ET without intrauterine administration | Frozen embryo transfer | Implantation Rate, Chemical pregnancy, Clinical pregnancy |
| Coksueret al., 2019 (32) | Turkey | Cohort | RIF: one or more failures of IVF-ET therapy without poor ovarian reserve | 34 | 36 | Intrauterine infusion of 1 ml of PRP | Underwent ET without intrauterine administration | Frozen embryo transfer | Clinical pregnancy, Miscarriage, Live Birth |