Table 1.
Representative activity-based probes and chemical reporters used to profile host proteins during infection.
| Probe | Chemical structure | Enzyme class/amino acid |
|---|---|---|
| FP-based probes[69, 71–72, 88, 115] |
|
Serine hydrolases |
| IA-alkyne[30] |
|
Reactive cysteine residues |
| 1-OH-Az[38] |
|
Reactive cysteine residues |
| ISG15-propargylamide[45–46] |
|
ISG15-based probe for cysteine proteases |
| DCG-04 linked to biotin[71] |
|
Papain-like cysteine proteases |
| AMS101[72] |
|
Vacuolar processing enzymes |
| ABP1[109] |
|
Rupintrivir-based probe for cysteine proteases |
| Desthiobiotin-FP[119] |
|
Serine hydrolases |
| TReNDs[51] |
|
Proteins AMPylated by Fic enzymes |