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. 2023 Sep 21;20:212. doi: 10.1186/s12974-023-02875-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Genetic ablation of Nrf2 aggravated the depression-like phenotypes with or without CUMS exposure in mice by regulating iron metabolism in neurons. A–G Body weight, SPT, OFT, TST and FST in the different indicated groups (control n = 12, CUMS n = 14, Nrf2^−/− control n = 10, Nrf2^−/− CUMS n = 15 mice). H The level of Fe in the serum of mice (control n = 7, CUMS n = 7, Nrf2^−/− control n = 8, Nrf2^−/− CUMS n = 8 mice). I and J Ferrous iron and total iron in the hippocampus of the different indicated groups (n = 6/group). K Immunofluorescence of the hippocampus costained with FtL (red) and the mature neuron marker NeuN (green) (n = 4/group; scale bars, 50 μm). L Immunofluorescence of the hippocampus costained with Tf (red) and the mature neuron marker NeuN (green) (n = 4/group; scale bars, 50 μm). M Immunofluorescence of the hippocampus costained with TfR (green) and the mature neuron marker NeuN (red) (n = 4/group; scale bars, 50 μm). All images of immunostaining were analysed with ImageJ software. Bars represent the mean ± SEM. Statistical analysis was performed by two-way ANOVA with Bonferroni’s post hoc test. Body weight data were analysed by two-way repeated measures analysis of variance. *Represents comparison with the control group, # represents comparison with the model group. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001