Fig. 5.

Overlap of T1D-relevant proteins with high- (HDL)/ low- (LDL) density lipoproteome. A Venn diagram showing common protein hits (grey) between the HDL/LDL proteome [52] (black) and those reported in our systematic review (white). B Venn diagram detailing the T1D stage as pre-seroconversion (pre-sero), post-seroconversion (post-sero) and post-diagnosis of the 119 HDL/LDL/T1D shared proteins from A. C Gene Ontology of HDL lipoprotein-known functions of pre-seroconversion reported proteins. D Heatmap of apolipoproteins with altered levels reported in at least one stage of T1D development. Up (Red color) are upregulated proteins and down (Green color) are downregulated proteins. Proteins are named using their UniProt gene names. Panel C was modified from a published figure by Davidson et al. (copyright permission was obtained from the publisher, license number: 5433910818199) [52]