Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Sep 21;21:248. doi: 10.1186/s12964-023-01281-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 2 — lncRNA Mir100hg promotes the metastatic activity of lung cancer cells in vitro and in vivo. A Heatmap of differentially expressed genes in GSE66616 dataset, MIR100HG(Red); B Boxplot of MIR100HG expression differences between non-invasive lung cancer cells and invasive lung cancer cells and fibroblasts; C Boxplot of MIR100HG expression levels in non-invasive lung cancer cells after co-culture with different fibroblast cells; D Differences in Mir100hg expression between LLC-SD and LLC cells; E Differences in Mir100hg expression between the exosomes of LLC-SD and LLC’s; F LLC-SD-exosomes (labeled with PKH26, Red) could be delivered to LLC cells; G The expression of Mir100hg in the supernatant treated with RNase A (2mg/mL) alone or in combination with Triton X-100 (0.1%) for 20 min was analyzed by RT-PCR. H Expression of Mir100hg in LLC after co-incubation of LLC-SD-exosomes for 20h; I The efficiency of Mir100hg overexpression in LLC; J-K Column chart of migration and invasion cells; L Lung metastasis was observed after tail vein injection of OE-Mir100hg-LLC (green). M HE staining was used to observe and quantify lung metastases. (*p < 0.05, **p < 0.01, ***p < 0.001)