TABLE 3.
The PK parameters of valsartan after oral T and R formulations under fasting and postprandial conditions.
| PK parameters | Fasting trial | Postprandial trial | ||
|---|---|---|---|---|
| Mean ± SD | Mean ± SD | |||
| T | R | T | R | |
| Tmax(h) | 3.24(1.49, 8.99) (N = 44) | 2.99(0.99, 6.99) (N = 87) | 4.49(0.99, 9.99) (N = 44) | 4.49(0.99, 5.99) (N = 84) |
| Cmax(ng/mL) | 2818.82 ± 1419.96 (N = 44) | 2799.64 ± 1385.07 (N = 87) | 1376.98 ± 473.07 (N = 44) | 1364.56 ± 534.53 (N = 84) |
| AUC0-t(h·ng/mL) | 16035.91 ± 6912.77 (N = 44) | 15873.30 ± 6751.62 (N = 87) | 8409.56 ± 3315.33 (N = 44) | 8329.16 ± 2911.29 (N = 84) |
| AUC0-∞(h·ng/mL) | 16496.43 ± 6959.21 (N = 44) | 16309.66 ± 6889.28 (N = 87) | 8910.50 ± 3225.82 (N = 43) | 8717.39 ± 3012.41 (N = 84) |
| λz(h-1) | 0.15 ± 0.05 (N = 44) | 0.13 ± 0.03 (N = 87) | 0.14 ± 0.04 (N = 44) | 0.14 ± 0.03 (N = 84) |
| t1/2(h) | 5.06 ± 1.36 (N = 44) | 5.58 ± 1.78 (N = 87) | 5.62 ± 1.80 (N = 43) | 5.46 ± 1.96 (N = 84) |