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. 2023 Sep 7;10:1261330. doi: 10.3389/fcvm.2023.1261330

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© 2023 Saito, Nose, Iida, Akazawa, Kanno, Fujimoto, Sasaki, Akehi, Higuchi, Akagi, Yoshida, Miyoshi, Ito and Nakamura.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NIS-expressing human induced pluripotent stem cells (iPSCs). (A) Immunostaining of immature markers and NIS in human iPSCs. Scale bars are 100 µm. (B) Uptake of ¹²⁵I in vitro. N = 3 in each, *p < 0.001 vs. NIS (+)/¹⁸F-tetrafluoroborate (TFB) and ¹²⁵I (ANOVA/Bonferroni). (C) Uptake of ¹⁸F- TFB in vitro. NaClO₄ is an inhibitor of NIS. N = 3 in each, *p < 0.001 vs. NIS (+)/¹⁸F-TFB and ¹²⁵I (ANOVA/Bonferroni).