Figure 5.

Enteroid/colonoid-informed machine learning approach identifies discriminating features of intestinal segment epithelium at homeostasis and in Crohn’s disease. (A) Outcome of testing the enteroid/colonoid-informed random forest model “tissue of origin classifier” on the dataset comprising biopsy-derived data. (B) Outcomes of testing the enteroid-informed support vector machine model “disease state classifier” on the dataset comprising the biopsy-derived data. (C) Outcomes of testing the enteroid-informed support vector machine model “disease state classifier” on the dataset comprising the rectal colonoid-derived data. CD, Crohn’s disease.