Figure 4.

The association between plasma D-dimer levels and adjusted hazard ratios of composite kidney progression outcome. Three knots at the 25th, 50th, and 75th percentiles were used to model the association between plasma D-dimer and composite kidney progression outcome, using restricted cubic splines. Model was adjusted for sex, age, proteinuria, MAP, eGFR and Oxford classification (MEST-C scores). the reference value was set at the medians. The histogram represents the distribution of plasma D-dimer in patients with IgA nephropathy; the solid line represents the estimated hazard ratio; the shaded area represents the 95% confidence interval.