Table 2.

Association of plasma D-dimer levels with the composite kidney disease progression outcome.

	Hazard Ratio, 95% Confidence Interval and P value
	Unadjusted	Model 1	Model 2	Model 3
Composite kidney disease progression events per ln (plasma D-dimer)	1.61(1.35-1.92) < 0.001	1.59(1.34-1.90) < 0.001	1.41(1.17-1.71) <0.001	1.61(1.24-2.08) <0.001
Plasma D-dimer tertiles
1	1 (Reference)	1 (Reference)	1 (Reference)	1 (Reference)
2	1.13 (0.71-1.81) 0.608	1.15 (0.71-1.84) 0.577	1.20(0.71-2.03) 0.507	1.25(0.65-2.40) 0.501
3	2.51(1.66-3.78) <0.001	2.48 (1.63-3.77) <0.001	2.05 (1.29-3.27) 0.003	2.54 (1.38-4.66) 0.003
P for trend	<0.001	<0.001	<0.001	0.003

CKD progression events were a 50% decrease in the eGFR or kidney failure.

Model 1 was adjusted for sex and age and sex was expressed as a dichotomous variable.

Model 2 was adjusted for the covariates in Model 1: mean arterial pressure, log-transformed proteinuria.

Model 3 was adjusted for covariates in Model 2 and Oxford classification (MEST-C scores).