Table 1.
Clinical characteristics of participants with different plasma fibrinogen levels.
| Total | Plasma fibrinogen level |
||||
|---|---|---|---|---|---|
| I tertile (n = 91) (≤3.5 g/L) | II tertile (n = 93) (3.5–4.4 g/L) | III tertile (n = 94) (≥4.4 g/L) | p Value | ||
| Age | 55.86 ± 16.54 | 47.16 ± 15.47 | 58.15 ± 16.16 | 63.76 ± 13.25 | <.001 |
| Male, n (%) | 168 (60.4%) | 56 (61.5%) | 51 (54.8%) | 52 (55.3%) | .540 |
| BMI (kg/m2) | 23.72 ± 3.81 | 22.67 ± 3.55 | 23.95 ± 4.00 | 24.57 ± 3.72 | .004 |
| History of smoking | 55 (19.8%) | 17 (18.7%) | 20 (21.5%) | 16 (17.0%) | .754 |
| History of diabetes | 68 (24.5%) | 33 (36.3%) | 41 (44.1%) | 32 (34.0%) | .006 |
| Use of statins | 165 (60.4%) | 44 (48.4%) | 56 (60.2%) | 62 (66.0%) | .001 |
| Use of hypotensive drugs | 258 (94.5%) | 85 (93.4%) | 87 (93.5%) | 77 (81.9%) | .948 |
| SBP (mmHg) | 130 (120, 141) | 127 (112, 140) | 130 (120, 141.5) | 131 (120, 140.5) | .684 |
| DBP (mmHg) | 80 (70, 90) | 80 (70, 90) | 80 (70, 90) | 80 (70, 85) | .121 |
| MAP | 97.44 ± 14.4 | 97.42 ± 16.04 | 97.87 ± 13.31 | 95.73 ± 13.23 | .586 |
| Dialysis-related variables | |||||
| CAPD, n (%) | 238 (85.6%) | 83 (91.2%) | 79 (94.9%) | 76 (80.9%) | .349 |
| PD duration (months) | 25.07 (23.92, 25.43) | 24.38 (23.89, 27.07) | 24.80 (23.92, 30.88) | 25.02 (23.85, 47.24) | .021 |
| nPCR (g/kg/24 h) | 0.88 (0.77, 1.03) | 0.96 (0.83, 1.08) | 0.88 (0.77, 1.01) | 0.81 (0.73, 0.94) | <.001 |
| Total Ccr (L/week) | 53.79 (47.34, 68.88) | 54.93 (47.87, 72.60) | 53.50 (46.61, 67.85) | 52.78 (46.89, 64.99) | .178 |
| Residual renal Ccr (L/week) | 9.90 (0, 33.14) | 12.42 (0.00, 38.74) | 14.51 (0, 33.05) | 6.42 (0, 26.17) | .145 |
| Total Kt/V | 1.79 (1.59, 2.03) | 1.82 (1.59, 2.05) | 1.82 (1.59, 2.02) | 1.78 (1.61, 2.02) | .320 |
| Residual renal Kt/V | 0.18 (0, 0.54) | 0.29 (0.00, 0.90) | 0.25 (0.00, 0.57) | 0.10 (0.00, 0.49) | .145 |
| Glucose absorption (g/24 h) | 86.62 (68.23, 116.25) | 79.8 (66.24, 109.63) | 81.99 (66.97, 110.35) | 99.07 (72.72, 121.93) | .170 |
| Volume of dialysate (per 1000 mL/24 h) | 8.04 (6.10, 9.02) | 6.60 (6.04, 8.85) | 6.83 (6.16, 9.04) | 8.43 (6.06, 9.03) | .185 |
| Biochemical parameters | |||||
| Fibrinogen (g/L) | 3.98 ± 1.15 | 2.88 ± 0.30 | 3.72 ± 0.27 | 5.18 ± 1.00 | <.001 |
| Hemoglobin (g/L) | 106.1 ± 17.2 | 103.43 ± 17.64 | 109.39 ± 16.33 | 105.42 ± 17.36 | .059 |
| Serum iron (μmol/L) | 12.35 (9.70, 16.10) | 13.60 (10.50, 16.95) | 13.20 (10.40, 17.35) | 10.85 (8.05, 13.85) | .031 |
| TSAT (%) | 31 (24, 39) | 33 (25, 43) | 32 (25.5, 41) | 26 (20, 32) | <.001 |
| Ferritin (ng/mL) | 210.9 (128.0, 305.0) | 241.0 (133.5, 339) | 193.2 (115.5, 277.5) | 209.5 (125.6, 332.5) | .09 |
| Albumin (g/L) | 36 (32, 39) | 36 (36, 41) | 37 (33, 40) | 35 (31, 38) | .074 |
| Calcium (mmol/L) | 2.25 ± 0.26 | 2.25 ± 0.31 | 2.28 ± 0.21 | 2.23 ± 0.25 | .349 |
| Phosphate (mmol/L) | 1.53 ± 0.43 | 1.60 ± 0.47 | 1.50 ± 0.40 | 1.49 ± 0.44 | .177 |
| iPTH (pg/mL) | 267.2 (167.0, 431.5) | 263.1 (164.0, 401.5) | 297 (187.0, 467.0) | 250.9 (159.08, 430.5) | .886 |
| CHO (mmol/L) | 4.34 ± 1.03 | 4.03 (3.39, 4.78) | 4.15 (3.72, 5.02) | 4.28 (3.66, 5.05) | .178 |
| TG (mmol/L) | 2.17 (1.66, 2.70) | 1.48 (1.11, 2.35) | 1.79 (1.23, 2.57) | 1.92 (1.19, 2.75) | .312 |
| LDL (mmol/L) | 1.72 (1.15, 2.55) | 2.04 (1.51, 2.69) | 2.22 (1.73, 2.71) | 2.13 (1.80, 2.60) | .510 |
| HDL (mmol/L) | 0.89 (0.75, 1.15) | 0.89 (0.75, 1.10) | 0.91 (0.75, 1.16) | 0.85 (0.74, 1.17) | .420 |
| ApoA1 (g/L) | 0.99 (0.87, 1.17) | 1.00 (0.88, 1.12) | 0.98 (0.89, 1.20) | 0.95 (0.83, 1.15) | .383 |
| ApoB (g/L) | 0.66 (0.56, 0.78) | 0.60 (0.53, 0.71) | 0.65 (0.59, 0.78) | 0.69 (0.61, 0.82) | .030 |
| NT-proBNP (per 1000 pg/mL) | 2.15 (0.78, 6.73) | 1.61 (0.63, 6.91) | 2.01 (0.77, 4.71) | 3.39 (1.19, 8.70) | .287 |
| hsCRP (mg/L) | 1.07 (0.44, 4.52) | 0.46 (0.25, 0.83) | 0.96 (0.50, 2.21) | 5.46 (2.05, 10.20) | <.001 |
| Echocardiographic measurements | |||||
| LVDd (cm) | 4.80 (4.40, 5.20) | 4.88 ± 0.64 | 4.83 ± 0.59 | 4.86 ± 0.71 | .866 |
| LVPW (cm) | 1.10 (0.90, 1.20) | 1.0 (0.9, 1.2) | 1.0 (0.9, 1.2) | 1.1 (1.0, 1.2) | .113 |
| IVST (cm) | 1.20 (1.00, 1.30) | 1.1 (0.9, 1.2) | 1.2 (1.0, 1.3) | 1.2 (1.1, 1.3) | .002 |
| MWT (cm) | 1.10 (0.95, 1.20) | 1.05 (0.90, 1.20) | 1.10 (0.95, 1.20) | 1.15 (1.00, 1.25) | .015 |
| RWT (cm) | 0.43 (0.38, 0.40) | 0.42 (0.38, 0.47) | 0.42 (0.38, 0.48) | 0.43 (0.39, 0.50) | .096 |
| LVMI (g.m–2.7) | 53.89 (43.89, 66.47) | 51.39 (41.58, 62.52) | 53.87 (43.59, 65.30) | 57.90 (46.23, 70.99) | .046 |
| LVEF (%) | 66.24 ± 7.07 | 68.77 ± 6.29 | 66.55 ± 7.07 | 65.81 ± 7.80 | .762 |
| E/A | 0.69 (0.58, 0.84) | 0.75 (0.65, 0.88) | 0.66 (0.57, 0.78) | 0.65 (0.50, 0.72) | .001 |
SBP: systolic blood pressure; DBP: diastolic blood pressure; MAP: mean arterial pressure; BMI: body mass index; Kt/V: urea clearance; Ccr: creatinine clearance; CAPD: continuous ambulatory peritoneal dialysis; TSAT: transferrin saturation; iPTH: intact parathyroid hormone; CHO: cholesterol; TG: triglyceride; LDL: low-density lipoprotein; HDL: high-density lipoprotein; ApoA1: apolipoprotein A1; ApoB: apolipoprotein B; NT-proBNP: N-terminal pro-brain natriuretic peptide; hsCRP: high-sensitivity C-reactive protein; LVDd: left ventricular end-diastolic diameter; IVST: interventricular septum thickness; PWT: posterior wall thickness; LVEF: left ventricular ejection fraction; MWT: mean wall thickness; RWT: relative wall thickness.