Table 2.
Genetic Predisposition of HCC.
| Signatures of causes | Mutations | Types of mutation | References |
|---|---|---|---|
| Polycystic aromatic hydrocarbon | Tobacco-Related (substitution mutation) | C to A substitutions | Jessica L Petrick et al., 2018 |
| Liver-specific Alcohol Related | Alcohol-related (CTNNB1) | T to C in ATN trinucleotide | Sandra Rebouissou et al., 2016 |
| HBV and AAV2 | Insertional Mutagenesis | TERT, CCNE1, CCNA2 | Cyriac A philps et al., 2021 |
| Mismatch Repair Defect | DNA modifications | C to T and Deletion Mutation | Graeme A Macdonald et al., 2003 |
| Age | Gene Modification | Demethylation of Methylcytosine | Manar Atyah et al., 2018 |
| Aristolochic Acid | Substitution Mutation | T to A in CTG trinucleotide | Jean Charles and Eric Latouze 2019 |
| Aflatoxin B1 | Substitution Mutation | C to A in GCC trinucleotide, | Laura Gramantieri et al., 2022 |