Table 2.
Reverse MR Results Between AMD and GM (P < 5 × 10−8)
| Exposure | Outcome | Method | nsnp | Beta | SE | Pval | OR | OR_lci95 | OR_uci95 |
|---|---|---|---|---|---|---|---|---|---|
| AMD | Anaerotruncus | Inverse variance weighted | 5 | 0.025 | 0.012 | 0.032 | 1.025 | 1.002 | 1.049 |
| AMD | Anaerotruncus | MR-Egger | 5 | 0.007 | 0.024 | 0.778 | 1.007 | 0.962 | 1.055 |
| AMD | Anaerotruncus | Weighted median | 5 | 0.022 | 0.013 | 0.092 | 1.022 | 0.996 | 1.048 |
| AMD | Anaerotruncus | Weighted mode | 5 | 0.023 | 0.013 | 0.166 | 1.023 | 0.996 | 1.051 |
| AMD | Candidatus Soleaferrea | Inverse variance weighted | 5 | 0.010 | 0.019 | 0.620 | 1.010 | 0.972 | 1.048 |
| AMD | Candidatus Soleaferrea | MR-Egger | 5 | 0.026 | 0.039 | 0.545 | 1.027 | 0.951 | 1.108 |
| AMD | Candidatus Soleaferrea | Weighted median | 5 | 0.016 | 0.021 | 0.453 | 1.016 | 0.975 | 1.059 |
| AMD | Candidatus Soleaferrea | Weighted mode | 5 | 0.016 | 0.022 | 0.494 | 1.016 | 0.974 | 1.061 |
| AMD | Eubacterium oxidoreducens group | Inverse variance weighted | 5 | 0.021 | 0.021 | 0.307 | 1.021 | 0.981 | 1.063 |
| AMD | Eubacterium oxidoreducens group | MR-Egger | 5 | 0.037 | 0.041 | 0.433 | 1.038 | 0.957 | 1.126 |
| AMD | Eubacterium oxidoreducens group | Weighted median | 5 | 0.022 | 0.022 | 0.326 | 1.022 | 0.978 | 1.068 |
| AMD | Eubacterium oxidoreducens group | Weighted mode | 5 | 0.023 | 0.023 | 0.372 | 1.023 | 0.978 | 1.070 |
| AMD | Faecalibacterium | Inverse variance weighted | 5 | −0.007 | 0.011 | 0.538 | 0.993 | 0.971 | 1.015 |
| AMD | Faecalibacterium | MR-Egger | 5 | 0.001 | 0.023 | 0.964 | 1.001 | 0.958 | 1.047 |
| AMD | Faecalibacterium | Weighted median | 5 | −0.004 | 0.012 | 0.742 | 0.996 | 0.972 | 1.020 |
| AMD | Faecalibacterium | Weighted mode | 5 | −0.004 | 0.013 | 0.795 | 0.996 | 0.971 | 1.022 |
| AMD | Ruminococcaceae UCG - 011 | Inverse variance weighted | 5 | 0.019 | 0.025 | 0.456 | 1.019 | 0.970 | 1.070 |
| AMD | Ruminococcaceae UCG - 012 | MR-Egger | 5 | −0.025 | 0.050 | 0.657 | 0.976 | 0.884 | 1.077 |
| AMD | Ruminococcaceae UCG - 013 | Weighted median | 5 | 0.013 | 0.030 | 0.667 | 1.013 | 0.955 | 1.075 |
| AMD | Ruminococcaceae UCG - 014 | Weighted mode | 5 | 0.003 | 0.030 | 0.934 | 1.003 | 0.945 | 1.063 |
| AMD | U nknown genus id.2071 | Inverse variance weighted | 5 | 0.015 | 0.013 | 0.260 | 1.015 | 0.989 | 1.042 |
| AMD | Unknown genus id.2071 | MR-Egger | 5 | 0.028 | 0.027 | 0.373 | 1.029 | 0.975 | 1.085 |
| AMD | U nknown genus id.2071 | Weighted median | 5 | 0.020 | 0.015 | 0.198 | 1.020 | 0.990 | 1.051 |
| AMD | U nknown genus id.2071 | Weighted mode | 5 | 0.022 | 0.016 | 0.244 | 1.023 | 0.990 | 1.056 |
nsnp, Number of SNP.