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. 2023 Sep 21;18(9):e0291799. doi: 10.1371/journal.pone.0291799

Table 4. Effect size of sleep duration on FT3 in prespecified and exploratory subgroups.

Character Total sleep duration Categories sleep duration
95% CI p p for interaction <7 7–9 >9 p for trend p for interaction
Sex 0.323 0.89
 Male -0.014(-0.028,0.001) 0.073 reference -0.053(-0.095,-0.011) -0.067(-0.159, 0.026) 0.01
 Female -0.024(-0.038,-0.009) 0.002 reference -0.058(-0.102,-0.013) -0.102(-0.210, 0.006) 0.008
AGE (years) 0.739 0.174
 >50 -0.019(-0.030,-0.008) 0.001 reference -0.038(-0.067,-0.008) -0.146(-0.234,-0.059) <0.001
 <50 -0.016(-0.030,-0.002) 0.029 reference -0.059(-0.104,-0.014) -0.057(-0.153, 0.039) 0.013
Race/Ethnicity 0.087 0.243
 White -0.031(-0.048,-0.014) <0.001 reference -0.081(-0.128,-0.034) -0.13(-0.238,-0.023) <0.001
 Black -0.012(-0.041,0.018) 0.435 reference -0.015(-0.079, 0.050) -0.239(-0.376,-0.103) 0.257
 Mexican 0.01(-0.027,0.048) 0.573 reference -0.008(-0.175,0.159) 0.091(-0.196,0.379) 0.956
 Other -0.012(-0.029,0.005) 0.164 reference -0.04(-0.103,0.022) -0.084(-0.183,0.015) 0.126
Ever told doctor had trouble sleeping? 0.536 0.889
 No -0.024(-0.039,-0.008) 0.003 reference -0.074(-0.119,-0.030) -0.117(-0.204,-0.030) <0.001
 Yes -0.033(-0.057,-0.009) 0.008 reference -0.067(-0.125,-0.010) -0.14(-0.246,-0.033) 0.016
Ever told by doctor have sleep disorder? 0.194 0.918
 No -0.019(-0.031,-0.006) 0.004 reference -0.062(-0.099,-0.024) -0.104(-0.180,-0.028) <0.001
 Yes -0.045(-0.083,-0.007) 0.020 reference -0.078(-0.182,0.026) -0.105(-0.340,0.129) 0.116
Smoke 0.408 0.178
 Never -0.027(-0.043,-0.012) <0.001 reference -0.078(-0.134,-0.021) -0.157(-0.248,-0.065) 0.003
 Former -0.021(-0.039,-0.003) 0.026 reference -0.026(-0.070, 0.018) -0.187(-0.308,-0.065) 0.077
 Now -0.012(-0.036,0.012) 0.318 reference -0.054(-0.125,0.017) 0.013(-0.100,0.126) 0.187
Alcohol. User 0.096 0.26
 Never -0.009(-0.027,0.009) 0.324 reference -0.031(-0.106,0.044) -0.071(-0.220,0.078) 0.3
 Former -0.035(-0.062,-0.009) 0.010 reference -0.088(-0.190, 0.013) -0.143(-0.283,-0.004) 0.055
 Mild -0.037(-0.052,-0.022) <0.0001 reference -0.093(-0.129,-0.057) -0.157(-0.306,-0.008) <0.0001
 Moderate -0.012(-0.033,0.009) 0.252 reference -0.024(-0.073,0.026) -0.205(-0.469,0.058) 0.212
 Heavy -0.003(-0.033,0.027) 0.842 reference -0.001(-0.094,0.093) -0.083(-0.280,0.113) 0.857
BMI (kg/m2) 0.013 0.069
 <25 -0.01(-0.030,0.010) 0.336 reference -0.063(-0.126,0.001) -0.067(-0.179,0.046) 0.042
 25–29.9 -0.041(-0.059,-0.023) <0.0001 reference -0.104(-0.164,-0.045) -0.136(-0.266,-0.006) <0.001
 ≥30 -0.013(-0.029,0.003) 0.119 reference -0.013(-0.068, 0.041) -0.135(-0.260,-0.011) 0.369
UIC (ug/dL) 0.285 0.189
 <100 -0.019(-0.041,0.002) 0.078 reference -0.046(-0.097,0.005) -0.078(-0.203,0.048) 0.071
 100–299 -0.014(-0.028,-0.001) 0.032 reference -0.05(-0.098,-0.003) -0.073(-0.191, 0.045) 0.028
 ≥300 -0.036(-0.060,-0.012) 0.004 reference -0.122(-0.195,-0.048) -0.141(-0.259,-0.022) 0.001
PIR 0.016 0.018
 <1 0.002(-0.015,0.020) 0.809 reference 0.014(-0.043,0.070) 0.025(-0.132,0.181) 0.598
 1–3.9 -0.025(-0.041,-0.009) 0.003 reference -0.06(-0.109,-0.011) -0.175(-0.265,-0.084) 0.003
 ≥4 -0.035(-0.056,-0.014) 0.002 reference -0.092(-0.146,-0.037) -0.086(-0.234, 0.061) <0.001
Marital 0.068 0.171
 Married, or living with partner -0.026(-0.039,-0.013) <0.001 reference -0.074(-0.118,-0.031) -0.055(-0.126, 0.016) 0.001
 Widowed, divorced, or separated -0.039(-0.063,-0.015) 0.002 reference -0.08(-0.142,-0.018) -0.265(-0.373,-0.158) 0.001
 Never married -0.004(-0.025,0.018) 0.725 reference -0.032(-0.103,0.040) -0.092(-0.233,0.050) 0.267

Each stratification adjusted for all factors (sex, age, race/ethnicity, marital status, BMI, sleep disturbance, poverty income ratio, smoking status, alcohol consumption status, UIC) except the stratification factor itself.