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. 2023 Sep 7;14:1255560. doi: 10.3389/fphar.2023.1255560

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Copyright © 2023 Wang, Tang, Zhao, Qin, Wang, Yang, Zhu and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TSTT promoted Shh/Gli1 co-localization in the hippocampal CA3 region and ischemic penumbra in PSCI rats. (A) Shh/Gli1 co-localization staining in the hippocampal CA3 region and ischemic penumbra, HP: scale bar = 500 μm; HP-Merge: scale bar = 50 μm; IP: scale bar = 200 μm; IP-Merge: 20 μm. (B) Expression of Shh, Ptch1, Smo, and Gli1 proteins in the hippocampus. (C) Population of Shh/Gli1-positive co-localization positive cells in the hippocampal CA3 area. (D) Population of Shh/Gli1-positive co-localization cells in the hippocampal IP area. (E) Relative expression of Shh. (F) Relative expression of Ptch1. (G) Relative expression of Smo. (H) Relative expression of Gli1. ^* p < 0.05 or ^** p < 0.01 vs. Sham group; ^# p < 0.05 or ^## p < 0.01 vs. MCAO group; n = 3.