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. 2023 Sep 7;10:1195656. doi: 10.3389/fmed.2023.1195656

Figure 3.

Figure 3

A proposed mechanism integrating scalp adipose metabolism in the pathogenesis of AGA. We hypothesize that adipogenesis in the bald AGA scalp is decreased via the downregulation of PPAR signaling via PPARγ, resulting in the reduction of the scalp adipose layer thickness. In effect, the resulting gap between the miniaturized HF and scalp adipose becomes even more prominent in the bald scalp, diminishing the corresponding action of adipocyte-derived factors (e.g., HGF and PDGFA) on the HFSC. As an effect, HFSC activation and differentiation are thereby reduced, along with adipogenesis in the scalp adipose tissue, creating an unfavorable environment for hair growth and regeneration.