Table 3.

Results of Brain Imaging in the MIND-Diet Group and the Control-Diet Group.^*

Imaging Result	MIND Diet		Control Diet		Difference (95% CI)†
	No. of Participants	Estimated Mean Change from Baseline (95% CI)	No. of Participants	Estimated Mean Change from Baseline (95% CI)
White-matter hyperintensities
Baseline	97	0 (Reference)	96	0 (Reference)
Year 3	97	0.086 (0.067 to 0.105)	96	0.105 (0.086 to 0.124)	−0.019 (−0.046 to 0.008)
Hippocampal volume
Baseline	101	0 (Reference)	99	0 (Reference)
Year 3	101	−0.075 (−0.09 to −0.06)	99	−0.080 (−0.095 to −0.065)	0.005 (−0.016 to 0.026)
Gray and white matter
Baseline	101	0 (Reference)	99	0 (Reference)
Year 3	101	−0.016 (−0.019 to −0.013)	99	−0.017 (−0.02 to −0.014)	0.001 (−0.003 to 0.005)

^*White-matter hyperintensities were standardized to intracranial volume, multiplied by 1000, and then log₁₀-transformed to normalize the data. Hippocampal volume is the average of the right and left hippocampus, which was then standardized to intracranial volume and multiplied by 1000. Gray and white matter is the sum of gray matter and white matter volumes of the brain, which were standardized to intracranial volume.

^†The widths of confidence intervals have not been adjusted for multiplicity and cannot be used to infer treatment effects.