. 2023 Feb 6;11(3):127–133. doi: 10.1016/j.prnil.2023.01.004

Table 2.

The comparison of oncologic outcomes between LDR brachytherapy and IMRT

	Number of patients	Procedure	Definition	Median follow-up	Outcomes
Zelefsky et al⁹ (2011)	729	LDR (144 Gy) (n = 448) vs. IMRT (81 Gy) (n = 281)	Phoenix	77 mo	Low 7-yr bPFS LDR: 95% IMRT: 89% P = 0.004
Spratt et al¹⁰ (2014)	870	LDR + EBRT (n = 400) vs. IMRT (86.4 Gy) (n = 470)	Phoenix	5.3 yr	Int. 7-yr bPFS LDR: 92% IMRT: 81% P = 0.004
Morris et al¹¹ (ASCENDE-RT) (2017)	398	DE-EBRT (78 Gy) (n = 195) vs. LDR + EBRT (n = 188)	Phoenix	78 mo	Int. ∼ High 7-yr bPFS LDR vs. DE-EBRT 86% vs. 75% P < 0.001

bPFS, biochemical progression-free survival; DE, dose escalated; EBRT, external beam radiation therapy; High, high-risk; IMRT, intensity modulated radiation therapy; Int., intermediate-risk; LDR, low-dose-rate brachytherapy; Low, low-risk.