Table 1.
LV volume and mass over time
| Sham | n | PVC-SC | n | PVC-LC | n | |
|---|---|---|---|---|---|---|
| LVEF (%) | ||||||
| Baseline | 61.8 ± 1.6 | 12 | 60.5 ± 1.4 | 15 | 62.0 ± 1.9 | 9 |
| Week 1 | 62.8 ± 1.8 | 10 | 51.3 ± 1.4 | 15∗† | 54.3 ± 1.9 | 9∗† |
| Week 2 | 63.7 ± 1.7 | 11 | 50.3 ± 1.7 | 15∗† | 54.9 ± 2.7 | 9∗† |
| Week 4 | 65.2 ± 1.6 | 12 | 49.6 ± 1.6 | 15∗† | 53.3 ± 2.5 | 9∗† |
| Week 8 | 63.2 ± 1.6 | 12 | 46.9 ± 1.6 | 15∗† | 47.3 ± 1.9 | 9∗† |
| Week 12 | 61.0 ± 1.6 | 12 | 47.1 ± 1.4 | 15∗† | 45.5 ± 2.0 | 8∗† |
| LVEDV (mL) | ||||||
| Baseline | 47.9 ± 2.5 | 12 | 49.8 ± 1.9 | 15 | 58.0 ± 2.6 | 9∗‡ |
| Week 1 | 49.2 ± 2.7 | 10 | 52.7 ± 2.2 | 15 | 57.2 ± 2.6 | 9∗ |
| Week 2 | 50.0 ± 2.6 | 11 | 53.7 ± 2.2 | 15 | 59.8 ± 2.6 | 9∗‡ |
| Week 4 | 50.9 ± 2.5 | 12 | 54.0 ± 2.2 | 15 | 62.1 ± 2.6 | 9∗‡ |
| Week 8 | 49.0 ± 2.5 | 12 | 55.8 ± 2.2 | 15∗ | 63.1 ± 2.6 | 9∗‡ |
| Week 12 | 51.6 ± 2.5 | 12 | 58.7 ± 2.2 | 15∗† | 66.3 ± 2.7 | 8∗‡ |
| LVESV (mL) | ||||||
| Baseline | 18.3 ± 1.5 | 12 | 19.8 ± 1.3 | 15 | 22.1 ± 1.7 | 9 |
| Week 1 | 18.3 ± 1.6 | 10 | 25.7 ± 1.3 | 15∗† | 26.2 ± 1.7 | 9∗ |
| Week 2 | 18.0 ± 1.5 | 11 | 26.5 ± 1.3 | 15∗† | 27.2 ± 1.7 | 9∗ |
| Week 4 | 17.8 ± 1.5 | 12 | 27.3 ± 1.3 | 15∗† | 29.1 ± 1.7 | 9∗† |
| Week 8 | 18.2 ± 1.5 | 12 | 29.7 ± 1.3 | 15∗† | 33.2 ± 1.7 | 9∗† |
| Week 12 | 20.3 ± 1.5 | 12 | 31.3 ± 1.3 | 15∗† | 36.5 ± 1.8 | 8∗†‡ |
| LV MI (L) (g/kg) | ||||||
| Baseline | 4.5 ± 0.2 | 12 | 4.5 ± 0.2 | 15 | 4.5 ± 0.2 | 9 |
| Week 1 | 5.1 ± 0.2 | 10 | 4.8 ± 0.2 | 15 | 4.5 ± 0.2 | 9 |
| Week 2 | 4.6 ± 0.2 | 11 | 4.9 ± 0.2 | 15 | 4.9 ± 0.2 | 9† |
| Week 4 | 5.1 ± 0.2 | 12 | 4.9 ± 0.2 | 15 | 4.7 ± 0.2 | 9 |
| Week 8 | 4.9 ± 0.2 | 12 | 5.1 ± 0.2 | 15† | 5.0 ± 0.2 | 9† |
| Week 12 | 4.8 ± 0.2 | 12 | 5.3 ± 0.2 | 15† | 4.9 ± 0.2 | 8 |
| LV MI (AL) (g/kg) | ||||||
| Baseline | 3.8 ± 0.2 | 12 | 3.8 ± 0.1 | 15 | 3.6 ± 0.2 | 9 |
| Week 1 | 4.0 ± 0.2 | 10 | 4.0 ± 0.1 | 15 | 4.1 ± 0.2 | 9† |
| Week 2 | 4.1 ± 0.2 | 11 | 4.1 ± 0.1 | 15 | 4.0 ± 0.2 | 9 |
| Week 4 | 4.0 ± 0.2 | 12 | 4.1 ± 0.1 | 15 | 4.2 ± 0.2 | 9† |
| Week 8 | 4.1 ± 0.2 | 12 | 4.5 ± 0.1 | 15† | 4.3 ± 0.2 | 9† |
| Week 12 | 3.9 ± 0.2 | 12 | 4.4 ± 0.1 | 15∗† | 4.2 ± 0.2 | 8† |
| RWT | ||||||
| Baseline | 0.40 ± 0.02 | 12 | 0.45 ± 0.02 | 15∗ | 0.46 ± 0.02 | 9 |
| Week 1 | 0.42 ± 0.02 | 10 | 0.43 ± 0.02 | 15 | 0.42 ± 0.02 | 9 |
| Week 2 | 0.41 ± 0.02 | 11 | 0.41 ± 0.02 | 15 | 0.40 ± 0.02 | 9† |
| Week 4 | 0.42 ± 0.02 | 12 | 0.38 ± 0.02 | 15† | 0.40 ± 0.02 | 9† |
| Week 8 | 0.42 ± 0.02 | 12 | 0.40 ± 0.02 | 15 | 0.38 ± 0.02 | 9† |
| Week 12 | 0.46 ± 0.02 | 12 | 0.38 ± 0.02 | 15∗† | 0.43 ± 0.02 | 8 |
Values are given as mean ± SEM unless otherwise indicated.
Multiple comparison test (P <.05): ∗vs sham; †vs baseline; ‡vs PVC-SC.
AL = area–length method; L = linear method; LV = left ventricle; LVEDV = left ventricular end-diastolic volume; LVEF = left ventricular ejection fraction; LVESV = left ventricular end-systolic volume; MI = mass index; PVC-LC = premature ventricular contraction long-coupled; PVC-SC = premature ventricular contraction short-coupled; RWT = relative wall thickness.