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. 2023 Aug 10;5(9):1544–1562. doi: 10.1038/s42255-023-00861-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, Invasive state signature scores represented by violin plots. b, UMAP plot coloured by the expression of the invasive state. c,d, GOBP terms enriched (hypergeometric tests) in the subset of genes (top 200) most highly correlated to the invasive signature scores in VR (c) or VR_RANO (d) cells. The dashed line indicates P = 0.05. Relevant UMAP plots coloured for the respective melanoma states are indicated. e, MITF activity state signature scores represented by violin plots. f, UMAP plot coloured by the expression of the MITF activity state. g,h, GOBP terms enriched (hypergeometric tests) in the subset of genes (top 200) most highly correlated to the MITF activity signature scores in VR (g) or VR_RANO (h) cells. The dashed line indicates P = 0.05. Relevant UMAP plots coloured for the respective melanoma states are indicated.