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. 2023 Jul 13;48(11):3255–3269. doi: 10.1007/s11064-023-03981-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Role of fibrinogen in MS: disruption of the blood–brain barrier (BBB) enhances leakage of fibrinogen from blood vessels. Deposited fibrinogen in the multiple sclerotic lesions leads to the activation of microglia and the release of pro-inflammatory cytokines. As well, fibrinogen triggers demyelination and inhibits remyelination