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. 2023 Jul 13;48(11):3255–3269. doi: 10.1007/s11064-023-03981-1

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Tropomyosin receptor kinase B (TrkB) in multiple sclerosis (MS): Fibrinogen increases the expression of tropomyosin receptor kinase B (TrkB) receptors in astrocytes. Over-expression of astrocytes TrkB is linked with morphological changes of astrocytes with subsequent over-production of nitric oxide (NO), the release of nitrotyrosine and reactive oxygen species (ROS) which promote MS