Table 3.

Multivariate analysis for progression free survival (PFS) and overall survival (OS).

		PFS		OS
Variable	Comparison	HR (95% CI)	p value	HR (95% CI)	p value
(A) Overall population
Sex	Female vs. Male	0.9882 (0.6198–1.530)	0.9588	0.9746 (0.6097–1.516)	0.9114
Age	(continuous)	0.9612 (0.9341–0.9890)	0.0066	0.9964 (0.9680–1.026)	0.8071
ECOG status	(continuous)	1.171 (0.8937–1.536)	0.2514	1.187 (0.9080–1.554)	0.2108
Smoke habit	Yes vs. No	1.220 (0.8285–1.798)	0.3136	1.048 (0.7010–1.568)	0.8195
Alcohol consumption	Yes vs. No	1.821 (1.156–2.837)	0.0087	1.110 (0.7223–1.675)	0.6254
Diabetes	Yes vs. No	0.3086 (0.2013–0.4674)	<0.0001	0.1599 (0.0947–0.2618)	<0.0001
(B) Diabetic population
Sex	Female vs. Male	0.9101 (0.4027–1.911)	0.8110	1.217 (0.5534–2.529)	0.6095
Age	(continuous)	0.9764 (0.9340–1.021)	0.2906	0.9907 (0.9439–1.041)	0.7071
ECOG status	(continuous)	1.410 (0.9429–2.121)	0.0954	1.249 (0.8237–1.922)	0.3013
Smoke habit	Yes vs. No	1.449 (0.7794–2.688)	0.2378	1.223 (0.6289–2.374)	0.5503
Alcohol consumption	Yes vs. No	2.301 (1.079–4.928)	0.0305	1.069 (0.5302–2.083)	0.8473
Metformin use	Yes vs. No	0.5827 (0.3148–1.085)	0.0851	0.5229 (0.2778–0.9870)	0.0438