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. Author manuscript; available in PMC: 2023 Oct 23.
Published in final edited form as: Cell Rep. 2023 Mar 22;42(4):112283. doi: 10.1016/j.celrep.2023.112283

Figure 3. Conditional ablation of Piezo2 function from TRPV1 or MrgprA3 lineage neurons significantly attenuates pruritogen-induced mechanical itch without affecting chemical itch.

Figure 3.

(A and B) Histamine-induced acute chemical itch (A) and mechanical itch (B) in Cre− (n = 8) and Cre+ (n = 10) Trpv1Cre; Piezo2f/f mice.

(C and D) CQ-induced acute chemical itch (C) and mechanical itch (D) in Cre− (n = 6) and Cre+ (n = 6) Trpv1Cre; Piezo2f/f mice.

(E and F) Histamine-induced acute chemical itch (E) and mechanical itch (F) in Cre− (n = 6) and Cre+ (n = 6) MrgprA3Cre; Piezo2f/f mice.

(G and H) CQ-induced acute chemical itch (G) and mechanical itch (H) in Cre− (n = 13) and Cre+ (n = 12) MrgprA3Cre; Piezo2f/f mice.

All data are expressed as mean ± SEM. n.s, not significant. *p < 0.05, **p < 0.01, ****p < 0.0001. Unpaired two-tailed Student’s t test.