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. 2023 Sep 21;13:15731. doi: 10.1038/s41598-023-42485-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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mRNA expression level of various secretases and kinases involved in neurodegeneration and processing of Aβ and p-tau leading to plague and NFTs in the precence of various concentrations of NSC-exos. qRT-PCR results revealed the suppression of (A) BACE1, (B) PESN, (C) acetylcholinesterase, (D) GSK-3β, and (E) CDK5 mRNA expression, and the enchancment of (F) ADAM10 mRNA expression. Data is expressed as the mean ± standard error of the mean (SEM) from three independent experiments (n = 3). * = p < 0.01 and ** = p < 0.001.