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. 2023 Sep 7;13:1239147. doi: 10.3389/fonc.2023.1239147

Table 3.

Association between Acute Leukemia and maternal nutrient intakes during pregnancy by child sex.

Quintiles of daily nutrients intake All Boys Girls
OR (95% CI)*
Protein, g 1.13 (0.96,1.34) 1.12 0.89,1.40) 1.07 (0.81,1.41)
Carbohydrates, g 0.86 (0.73,1.02) 0.98 (0.78,1.23) 0.76 (0.57,1.01)
Fiber, g 0.86 (0.72,1.02) 0.91 (0.72,1.15) 0.76 (0.56,1.03)
Saturated fat, g 1.28 (1.08,1.52) 1.16 (0.93,1.45) 1.49 (1.09,2.04)
Monosaturated fat, g 1.08 (0.91,1.27) 1.03 (0.81,1.30) 1.07 (0.82,1.40)
Polyunsaturated fat, g 0.92 (0.77,1.09) 0.86 (0.67,1.10) 1.05 (0.80,1.37)
Cholesterol, mg 1.19 (0.99,1.42) 1.27 (0.99,1.62) 1.05 (0.78,1.41)
Retinol, mcg 1.13 (0.95,1.35) 1.22 (0.96,1.56) 1.00 (0.75,1.34)
Alpha carotene, mcg 0.97 (0.81,1.15) 1.07 (0.84,1.36) 0.89 (0.67,1.18)
Beta carotene, mcg 0.89 (0.75,1.05) 1.02 (0.80,1.30) 0.78 (0.59,1.04)
Thiamine, B1, mg 0.83 (0.70,0.99) 1.06 (0.83,1.35) 0.58 (0.43,0.79)
Riboflavin, B2, mg 1.15 (0.97,1.36) 1.33 (1.04,1.69) 0.93 (0.71,1.23)
Niacin, B3, mg 0.77 (0.65,0.92) 0.95 (0.75,1.21) 0.57 (0.41,0.78)
Pyridoxine, B6, mg 0.77 (0.64,0.93) 0.87 (0.69,1.12) 0.54 (0.38,0.76)
Folate, mcg 0.80 (0.67,0.94) 1.00 (0.79,1.25) 0.55 (0.40,0.76)
Vitamin B12, mcg 0.99 (0.83,1.17) 1.10 (0.87,1.39) 0.76 (0.56,1.03)
Vitamin C, mg 0.84 (0.71,0.99) 1.02 (0.80,1.28) 0.63 (0.47,0.86)
Alpha tocopherol, mg 0.81 (0.68,0.96) 0.87 (0.70,1.10) 0.68 (0.51,0.91)
Vitamin K, mcg 0.91 (0.77,1.09) 0.96 (0.75,1.22) 0.79 (0.58,1.07)
Choline, mg 1.11 (0.93,1.32) 1.25 (0.98,1.59) 0.88 (0.66,1.17)
Calcium, mg 1.13 (0.95,1.33) 1.14 (0.91,1.42) 1.07 (0.81,1.42)
Phosphorus, mg 1.23 (1.04,1.46) 1.10 (0.88,1.38) 1.36 (1.02,1.82)
Magnesium, mg 1.03 (0.87,1.22) 1.00 (0.79,1.26) 1.00 (0.75,1.33)
Iron, mg 0.74 (0.62,0.89) 0.96 (0.76,1.22) 0.47 (0.34,0.67)
Zinc, mg 1.06 (0.90,1.25) 0.97 (0.77,1.22) 1.06 (0.81,1.40)
Copper, mg 0.86 (0.72,1.02) 1.01 (0.80,1.29) 0.69 (0.52,0.92)
Sodium, mg 0.95 (0.80,1.12) 1.12 (0.89,1.41) 0.75 (0.55,1.00)
Potassium, mg 0.89 (0.75,1.05) 0.93 (0.74,1.17) 0.77 (0.57,1.03)
Caffeine, mg 0.87 (0.73,1.03) 0.89 (0.70,1.12) 0.86 (0.65,1.14)
Theobromine, mg 1.02 (0.86,1.21) 1.00 (0.79,1.27) 1.16 (0.87,1.55)
Methionine, g 1.23 (1.03,1.46) 1.14 (0.91,1.43) 1.25 (0.93,1.69)
Betaine, mg 0.90 (0.76,1.06) 1.05 (0.83,1.33) 0.73 (0.55,0.98)

*Adjusted by state of residence, person/room ratio, breastfeeding, maternal age at pregnancy, as well as maternal tobacco and alcohol consumption and supplement use of iron and vitamins during pregnancy. Bold and shadowed numbers correspond to case-control OR differences > or <1.00 with P-value <0.05.