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. 2023 Sep 21;6(12):e202301966. doi: 10.26508/lsa.202301966

Figure 2. High MAP4K1 levels are correlated with poor prognosis in glioma patients.

Figure 2.

(A) Heatmap (left) and statistical analysis (right) of MAP4K1 mRNA expression in human normal brain (n = 19) and glioma tissues (n = 39). The data were collected from the Cancer RNA-Seq Nexus platform (GSE59612). Data are represented as single data points and mean ± SD. ***P < 0.001 (t test). (B) Analysis of MAP4K1 mRNA levels in normal cerebral cortex samples (n = 207), glioblastoma multiforme (n = 166), and low-grade gliomas (n = 523). The data were from The Cancer Genome Atlas. Data are represented as single data points and mean ± SD (t test). (C, D) MAP4K1 mRNA expression in different pathological grades (II–IV). The data were from batch 2 ((C), n = 306) and batch 1 ((D), n = 554) of the Chinese Glioma Genome Atlas (CGGA). Data are represented as single data points and mean ± SD. *P < 0.05, **P < 0.01, ****P < 0.0001 (one-way ANOVA). (E, F) Cases of high and low MAP4K1 mRNA levels in different pathological grades (II–IV). The data were from CGGA batch 2 ((E), grade II, low n = 59, high n = 40; grade III, low n = 41, high n = 32; grade IV, low n = 53, high n = 81) and batch 1 ((F), grade II, low n = 83, high n = 66; grade III, low n = 113, high n = 93; grade IV, low n = 82, high n = 117). Data are represented as single data points and mean ± SD. ns, no significance, *P < 0.05, **P < 0.01 (χ2 test). (G, H, I) Analysis of MAP4K1 mRNA levels according to isocitrate dehydrogenase gene (IDH) phenotypes, WT or mutation (mut), in all grades of gliomas ((G), n = 306) and glioblastoma multiforme ((H), n = 134), and 1p/19q status (codeletion or non-codeletion) in all grades of gliomas ((I), n = 306). The data were from CGGA (batch 2). Data are represented as single data points and mean ± SD. ****P < 0.0001 (t test). (J, K) Overall survival analysis of MAP4K1-low and -high groups of glioma patients. The data were from CGGA batch 2 ((J), n = 306) and batch 1 ((K), n = 554). *P < 0.05, ****P < 0.0001 (Kaplan‒Meier method, log-rank test). (E, F, J, K) The samples were categorized into MAP4K1-low and -high groups using median expression levels of MAP4K1 mRNA as the cutoff value in (E, F, J, K).