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. 2023 Sep 21;6(12):e202301966. doi: 10.26508/lsa.202301966

Figure 5. MAP4K1 silencing alters transcriptomic profiling of glioblastoma multiforme cells.

Figure 5.

(A) Kyoto Encyclopedia of Genes and Genome pathway enrichment analysis of transcriptome data based on differentially expressed genes in MAP4K1-knockdown (KD) T98G cells and their negative control (NC). Cytokine‒cytokine receptor interaction and PI3K-AKT signaling were among the top three enriched pathways. (B) Heatmap of differentially expressed genes in the cytokine‒cytokine receptor pathways (left, up-regulated genes; right, down-regulated genes. IL-18R and IL-6R are down-regulated with MAP4K1-KD in T98G cells.