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. 2023 Sep 21;6(12):e202301966. doi: 10.26508/lsa.202301966

Figure 6. MAP4K1 is correlated with cytokine‒cytokine receptor interactions and chemokine signaling pathways in human gliomas.

Figure 6.

(A, B) Heatmap (A) and volcano plot (B) show differentially expressed genes in MAP4K1-high and -low human glioblastoma multiforme. The data were from The Cancer Genome Atlas-glioblastoma multiforme dataset (n = 166) and categorized into high- and low-expression groups using median expression levels of MAP4K1 mRNA as the cutoff value. (C, D, E) Gene Set Enrichment Analysis pathway enrichment analysis based on differentially expressed genes in MAP4K1-high and -low groups (C). (D) MAP4K1 is positively correlated with cytokine–cytokine receptor interactions. P = 0.000103, NES = 2.872095, Q-value = 0.000550. (E) MAP4K1 is positively correlated with chemokine signaling pathways. P = 0.000106, NES = 2.707719, Q-value = 0.000551. (F) Correlation analysis of MAP4K1 mRNA levels with IL-18R and IL-6R levels. The data were from batch 2 and batch 1 of the Chinese Glioma Genome Atlas (batch 2, n = 325, batch 1, n = 693, r and P-values are indicated).