FIGURE 2.

Potential impact of combination between chimeric antigen receptor T lymphocytes (CAR‐T) cell and immunoregulatory non‐coding RNA (ncRNA). A schematic diagram illustrates the potential impact of combining CAR‐T cells and circRNA for improving the response to CAR‐T‐cell therapy. As presented in section (1), circRNAs can combined with CAR‐T cells construction by cloning circRNA in the CAR‐Vector or transfecting CAR‐T cells with the plasmid of circRNA candidate. Section (2): the combination of CAR‐T cell with immunoregulatory ncRNA could improve not only the function of CAR‐T cells but also the response of tumour‐infiltrating immune cells such as effector T cells, cytotoxic T cells, natural killer (NK) cells and activated macrophages besides improving the susceptibility of cancer cells to immunotherapy intervention.