Figure 4.

Association between immune cell infiltration and response to lenvatinib plus PD-1 inhibitors in 20 patients with HCC. Response was assessed by IIR per mRECIST. (A) The differences between the response and non-response groups for CD8⁺ T cells, M1 macrophages, M2 macrophages, CD56^dim NK cells, and CD56^bright NK cells. (B) The representative images of immunohistochemical staining of tumor-infiltrating immune cells. Cells with only CD68 expression were considered M2 macrophages, and dual-labeled cells for CD68 and HLA-DR were considered M1 macrophages. HCC, hepatocellular carcinoma; IIR, independent imaging review; mRECIST, modified Response Evaluation Criteria in Solid Tumors; NK, natural killer; NR, non-response; PD, progressive disease; PD-1, programmed cell death protein-1; PR, partial response; R, response; SD, stable disease; HLA-DR, human leukocyte antigen DR.