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. 2023 Aug 24;9(5):49. doi: 10.3390/ncrna9050049

Figure 2.

Figure 2

Relative expression levels (real-time PCR) of hsa-miR-21-5p and hsa-miR-29c-3p in native and CRISPR/Cas9-modified ASC52telo cells and their EV fractions; n ≥ 3. Groups: ASC52telo—native cell culture; C1, C2, etc.—clones treated with the CRISPR/Cas9 system in combination with scramble gRNAs; 21.x—clones treated with the CRISPR/Cas9 system in combination with guide RNAs to hsa-miR-29c; 29c.x—clones treated with the CRISPR/Cas9 system in combination with guide RNAs to hsa-miR-29c; bulk—cells with modification before cloning. * p < 0.05, compared to the appropriate control group (C bulk—for the left panel, ASC52 telo—for the right panel), n = 3, t-test.