Table 3.

Comparison between the two studied groups according to rs5749201 and rs886471.genotype frequencies.

	SLE (n = 145)	Control® (n = 145)	χ2 (p)	OR (LL–UL 95%C.I)	p 0
rs5749201
Genotype
TT®	15 (10.3%)	(60 + 0) 60 (41.4%)	55.696 * (<0.001 *)	1.0
TA	48 (33.1%)	(19 + 39) 58 (40.0%)		3.310 (1.672–6.553)	0.001 *
AA	82 (56.6%)	(66 − 39) 27 (18.6%)		12.148 (5.951–24.799)	<0.001 *
Dominant TA + AA vs. TT®	130/15	85/60	36.419 * (<0.001 *)	6.118 (3.263–11.468)	<0.001 *
Recessive AA vs. TT + TA®	82/63	27/118	44.465 * (<0.001 *)	5.688 (3.343–9.680)	<0.001 *
Allele	(n = 290)	(n = 290)
T®	78 (26.9%)	178 (61.4%)	69.927 * (<0.001 *)	1.0
A	212 (73.1%)	112 (38.6%)		4.320 (3.041–6.136)	<0.001 *
rs886471
Genotype
TT®	16 (11.0%)	(65 + 0) 65 (44.8%)	59.351 (<0.001 *)	1.0
TG	50 (34.5%)	(17 + 39) 56 (38.6%)		3.627 (1.862–7.066)	<0.001 *
GG	79 (54.5%)	(63 − 39) 24 (16.6%)		13.372 (6.557–27.272)	<0.001 *
Dominant TG + GG vs. TT®	129/16	80/65	41.130 * (<0.001 *)	6.551 (3.545–12.105)	<0.001 *
Recessive GG vs. TT + TG®	79/66	24/121	45.545 * (<0.001 *)	6.035 (3.545–12.105)	<0.001 *
Allele	(n = 290)	(n = 290)
T®	82 (28.3%)	186 (64.1%)	75.025 * (<0.001 *)	1.0
G	208 (71.7%)	104 (35.9%)		4.537 (3.195–6.441)	<0.001 *
Haplotype	(n = 290)	(n = 290)
TT®	73 (25.2%)	178 (61.4%)	82.464 * (MC p < 0.001 *)	1.0
TG	5 (1.7%)	0 (0.0%)		–	0.999
AT	9 (3.1%)	8 (2.8%)		2.743 (1.019–7.387)	0.046 *
AG	203 (70.0%)	104 (35.9%)		4.759 (3.318–6.826)	<0.001 *

^®: Reference group; OR: Odd’s ratio; C.I: Confidence interval; LL: Lower limit; UL: Upper Limit; χ²: Chi square test; MC: Monte Carlo; p₀: p value for binary logistic regression; p: p value for comparing between the two studied groups; *: Statistically significant at p ≤ 0.05.