Table 5.
Relation between rs5749201 and different parameters in SLE patients (n = 145).
| rs5749201 | Test of Sig. | p | TT vs. TA | TT vs. AA | TA vs. AA | |||
|---|---|---|---|---|---|---|---|---|
| TT (n = 15) | TA (n = 48) | AA (n = 82) | ||||||
| Age (years) | 36.1 ± 5.95 | 37.4 ± 8.89 | 42.8 ± 6.37 | F = 11.382 * | <0.001 * | 0.837 | 0.004 * | <0.001 * |
| Sex | ||||||||
| Male | 0 (0%) | 3 (6.3%) | 18 (22%) | χ2 = 8.860 * | 0.012 * | 1.000 a | 0.066 a | 0.019 * |
| Female | 15 (100%) | 45 (93.8%) | 64 (78%) | |||||
| Disease Duration (years) | 2.80 ± 1.07 | 4.09 ± 3.19 | 8.15 ± 6.45 | H = 16.053 * | <0.001 * | 0.466 | 0.003 * | 0.001 * |
| Malar rash | 10 (66.7%) | 21 (43.8%) | 50 (61.0%) | χ2 = 4.436 | 0.109 | – | – | – |
| Discoid rash | 3 (20.0%) | 17 (35.4%) | 18 (22.0%) | χ2 = 3.172 | 0.205 | – | – | – |
| Photosensitivity | 3 (20.0%) | 8 (16.7%) | 11 (13.4%) | χ2 = 0.552 | 0.759 | – | – | – |
| Arthritis | 4 (26.7%) | 42 (87.5%) | 58 (70.7%) | χ2 = 20.95 * | <0.001 * | <0.001 *a | 0.001 * | 0.029 * |
| Mucosal ulcers | 7 (46.7%) | 8 (16.7%) | 26 (31.7%) | χ2 = 6.167 * | 0.046 * | 0.033 *a | 0.261 | 0.060 |
| Renal affection | 2 (13.3%) | 9 (18.8%) | 59 (72.0%) | χ2 = 42.5 * | <0.001 * | 1.0 a | <0.001 * | <0.001 * |
| Anemia | 14 (93.3%) | 39 (81.3%) | 77 (93.9%) | χ2 = 4.935 | 0.067 b | – | – | – |
| WBC Leukopenia | 15 (100%) | 22 (45.8%) | 66 (80.5%) | χ2 = 24.494 * | <0.001 * | <0.001 * | 0.069 a | <0.001 * |
| thrombocytopenia | 1 (6.7%) | 23 (47.9%) | 65 (79.3%) | χ2 = 33.682 * | <0.001 * | 0.004 * | <0.001 *a | <0.001 * |
| CRP | 52.3 ± 18.0 | 45.2 ± 24.9 | 55.1 ± 19.1 | H = 11.579 * | 0.003 * | 0.587 | 0.015 * | 0.004 * |
| ESR | 35.0 ± 4.14 | 42.3 ± 30.8 | 66.2 ± 29.5 | H = 26.877 * | <0.001 * | 0.221 | <0.001 * | <0.001 * |
| Protein/Creatinine ratio | 0.22 ±0.19 | 0.42 ± 0.64 | 0.83 ± 0.93 | H = 31.173 * | <0.001 * | 0.153 | 0.038 * | <0.001 * |
| C3 (mg/dL) | 105 ±17.7 | 90.5 ± 34.9 | 72.6 ± 32.0 | H = 22.064 * | <0.001 * | 0.096 | <0.001 * | 0.001 * |
| C4 (mg/dL) | 22.3 ± 2.84 | 16.5 ± 8.10 | 11.9 ± 8.81 | H = 29.120 * | <0.001 * | 0.034 * | <0.001 * | <0.001 * |
| ANA | 15 (100%) | 44 (91.7%) | 81 (98.8%) | χ2 = 4.002 | 0.090 b | – | – | – |
| ds-DNA | 3 (20.0%) | 42 (87.5%) | 79 (96.3%) | χ2 = 59.90 * | <0.001 * | <0.001 *a | <0.001 *a | 0.075 a |
| SLEDAI | ||||||||
| High (11–19) | 0 (0.0%) | 7 (14.6%) | 40 (48.8%) | χ2 = 24.186 * | <0.001 * | 0.182 a | <0.001 * | <0.001 * |
| Very high (≥20) | 3 (20.0%) | 2 (4.2%) | 22 (26.8%) | χ2 = 10.283 * | 0.006 * | 0.083 a | 0.753 a | 0.001 * |
Quantitative data was expressed using Mean ± SD; SD: Standard deviation; χ2: Chi square test; a: Fisher Exact; b: Monte Carlo; F: F for One way ANOVA test, Pairwise comparison bet. each 2 groups was done using Post Hoc Test (Tukey); H: H for Kruskal Wallis test, Pairwise comparison bet. each 2 groups was done using Post Hoc Test (Dunn’s for multiple comparisons test). *: Statistically significant at p ≤ 0.05.