Table 6.
Relation between rs886471 and different parameters in SLE patients (n = 145).
| rs886471 | Test of Sig. | p | TT vs. TG | TT vs. GG | TG vs. GG | |||
|---|---|---|---|---|---|---|---|---|
| TT (n = 16) | TG (n = 50) | GG (n = 79) | ||||||
| Age (years) | 37.6 ± 5.1 | 37.2 ± 9.14 | 42.9 ± 6.27 | F = 10.725 * | <0.001 * | 0.980 | 0.023 * | <0.001 * |
| Sex | ||||||||
| Male | 0 (0%) | 4 (8.0%) | 17 (21.5%) | χ2 = 7.564 * | 0.023 * | 0.565 | 0.067 a | 0.043 * |
| Female | 16 (100%) | 46 (92.0%) | 62 (78.5%) | |||||
| Disease duration (years) | 4.03 ± 3.23 | 3.73 ± 3.01 | 8.30 ± 6.43 | H = 18.365 * | <0.001 * | 0.589 | 0.031 * | <0.001 * |
| Malar rash | 10 (62.5%) | 22 (44.0%) | 49 (62.0%) | χ2 = 4.356 | 0.113 | – | – | – |
| Discoid rash | 3 (18.8%) | 17 (34.0%) | 18 (22.8%) | χ2 = 2.509 | 0.285 | – | – | – |
| Photosensitivity | 5 (31.3%) | 7 (14.0%) | 10 (12.7%) | χ2 = 3.655 | 0.161 | – | – | – |
| Arthritis | 4 (25.0%) | 43 (86.0%) | 57 (72.2%) | χ2 = 22.25 * | <0.001 * | <0.001 *a | <0.001 * | 0.066 |
| Mucosal ulcers | 8 (50.0%) | 7 (14.0%) | 26 (32.9%) | χ2 = 9.585 * | 0.008 * | 0.006 *a | 0.194 | 0.016 * |
| Renal affection | 2 (12.5%) | 12 (24.0%) | 56 (70.9%) | χ2 = 36.2 * | <0.001 * | 0.488 a | <0.001 * | <0.001 * |
| Anemia | 16 (100%) | 40 (80%) | 74 (93.7%) | χ2 = 8.245 * | 0.016 * | 0.102 a | 0.585 a | 0.018 * |
| Leucopenia | 15 (93.8%) | 24 (48.0%) | 64 (81.0%) | χ2 = 20.729 * | <0.001 * | 0.001 * | 0.293 a | <0.001 * |
| thrombocytopenia | 1 (6.3%) | 23 (46.0%) | 65 (82.3%) | χ2 = 40.059 * | <0.001 * | 0.004 * | <0.001 *a | <0.001 * |
| CRP | 46.2 ± 23.1 | 44.7 ± 24.9 | 56.9 ± 17.0 | H = 18.910 * | <0.001 * | 0.357 | 0.001 * | <0.001 * |
| ESR | 44.4 ± 29.6 | 39.2 ± 26.7 | 67.2 ± 29.0 | H = 27.795 * | <0.001 * | 0.960 | 0.001 * | <0.001 * |
| Protein/creatinine ratio | 0.43 ± 0.67 | 0.43 ± 0.64 | 0.80 ± 0.93 | H = 28.119 * | <0.001 * | 0.112 | 0.069 | <0.001 * |
| C3 (mg/dL) | 103 ± 20.4 | 92.5 ± 33.9 | 70.9 ± 31.7 | H = 24.682 * | <0.001 * | 0.238 | <0.001 * | <0.001 * |
| C4 (mg/dL) | 21.6 ± 3.76 | 17.2 ± 8.12 | 11.4 ± 8.56 | H = 35.036 * | <0.001 * | 0.084 | <0.001 * | <0.001 * |
| ANA | 16 (100%) | 46 (92.0%) | 78 (98.7%) | χ2 = 3.671 | 0.105 b | – | – | – |
| ds-DNA | 5 (31.3%) | 43 (86.0%) | 76 (96.2%) | χ2 = 45.34 * | <0.001 * | <0.001 *a | <0.001 *a | 0.046 *a |
| SLEDAI | ||||||||
| High (11–19) | 0 (0%) | 7 (14.0%) | 40 (50.6%) | χ2 = 27.382 * | <0.001 * | 0.181 a | <0.001 * | <0.001 * |
| Very high (≥20) | 2 (12.5%) | 4 (8.0%) | 21 (26.6%) | χ2 = 7.422 * | 0.024 * | 0.627 a | 0.342 a | 0.009 * |
Quantitative data was expressed using Mean ± SD; SD: Standard deviation; χ2: Chi square test; a: Fisher Exact; b: Monte Carlo; F: F for One way ANOVA test, Pairwise comparison bet. each 2 groups were done using Post Hoc Test (Tukey); H: H for Kruskal Wallis test, Pairwise comparison bet. each 2 groups were done using Post Hoc Test (Dunn’s for multiple comparisons test); p: p value for relation between rs5749201 and different parameters; *: Statistically significant at p ≤ 0.05.