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Intervention with ErbB2-4 expression re-sensitizes Rego-resistant HCC cells. (A-E) Dose-response curves of Rego-resistant SNU449 cells against Regorafenib upon siRNA-mediated knockdown of EGFR (A), ErbB2 (B), ErbB3 (C), ErbB4 (D) and Axl (E). Bar charts show the respective IC50 values (µM). Data are expressed as mean +/- SD. ns: p > 0.05; *p ≤ 0.05. NT, Non-Target.
