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. 2023 Sep 8;13:1238883. doi: 10.3389/fonc.2023.1238883

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Copyright © 2023 Breitenecker, Hedrich, Pupp, Chen, Řezníčková, Ortmayr, Huber, Weber, Balcar, Pinter and Mikulits

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Resistance to Rego induces bFGF secretion. (A, B) Quantification of growth factor signals comparing control (ctrl, naïve) and Rego-resistant SNU449 cells in the Axl-proficient (A) and Axl-deficient background (B). Bar charts depicts relative abundance of growth factors to their respective naïve control. Black lines indicate unchanged growth factor levels (A, B). (C) Levels of bFGF in sera of naïve and 2^nd line Rego-treated HCC patients and supernatants of control (white) and Rego-resistant SNU449 cells as determined by ELISA. (D) bFGF levels in supernatants of control (white) and Sora- and Rego-resistant SNU449-Axl^- cells (grey, black) as determined by ELISA. Data are expressed as mean +/- SD. ns: p > 0.05; *p < 0.05. ***p ≤ 0.001. Rego, Regorafenib; Sora, Sorafenib.