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. 2023 Sep 8;13:1238883. doi: 10.3389/fonc.2023.1238883

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Copyright © 2023 Breitenecker, Hedrich, Pupp, Chen, Řezníčková, Ortmayr, Huber, Weber, Balcar, Pinter and Mikulits

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of the resistance mechanism of HCC cells to Rego. Axl and ErbB2-4 are co-upregulated in HCC cells resistant to Rego. bFGF levels increase upon acquiring resistance to Rego.