Table 2.
NcRNAs as diagnostic or prognostic biomarkers in different types of NSCLC.
| NSCLC subtypes | NcRNA subtypes | Samples | Techniques | Expression patterns | Biomarker types | Potential values | Reference | |
|---|---|---|---|---|---|---|---|---|
| LUAD | miRNA | miR-30d-5p | Serum | RT-qPCR | Down | Prognosis | High of miR-30d-5p was closely correlated with longer RFS in LUAD (p = 0.02). | (199) |
| miRNA-30a-5p | Serum | qRT-PCR | Down | Prognosis | AUC = 0.902. Low levels of miR-30d-5p were closely correlated with worse clinical outcomes in LUAD. | (200) | ||
| miR-125b-5p | Tissue | Bioinformatics | Down | Prognosis | AUC = 0.768. Low levels of miR-125b-5p were closely associated with poor OS and DFS in LUAD (p < 0.0001). | (201) | ||
| miR4732-5p, miR451a, miR486-5p, and miR139-3p | Serum exosome | qRT-PCR | UP | Diagnosis | AUC = 0.8554, 91.07% sensitivity and 66.36% specificity. | (19) | ||
| lncRNA | CASC11 | Tissue, plasma | qRT-PCR | UP | Diagnosis Prognosis | CASC11 exhibited diagnostic value in LUAD (p < 0.0001). High CASC11 levels were closely correlated with poor prognosis in LUAD (p < 0.05). | (202) | |
| IPW | Tissue, cell | Bioinformatics, qRT-PCR | Down | Prognosis | High levels of miR-370 were closely correlated with shorter OS in LUAD (p = 0.045). | (203) | ||
| SIGLEC17P | Tissue | Bioinformatics, qRT-PCR | Down | Prognosis | AUC = 1.000 (p < 0.01). LUAD patients with high SIGLEC17P levels exhibited good OS (p = 0.0009) and RFS (p = 0.0053). | (204) | ||
| circRNA | hsa_circ_101555, hsa_circ_008068 | Tissue, plasma | qPCR | Up | Diagnosis | AUC for hsa_circ_101555 was 0.708 (76.67% sensitivity and 60.00% specificity); AUC for hsa_circ_008068 was 0.624 (63.33% sensitivity and 53.33% specificity). | (205) | |
| hsa_circ_0001492, hsa_circ_0001439, hsa_circ_0000896 | Serum, serum exosome | qRT-PCR | Up | Diagnosis | The AUC value of the combination of exosomal hsa_circ_0001492, hsa_circ_0001439, and hsa_circ_0000896 was 0.805. | (206) | ||
| LUSC | miRNA | miRNA-126-3p | Tissue | qRT-PCR | Down | Diagnosis Prognosis | AUC = 0.6748 (p = 0.018). LUSC patients with low miRNA-126-3p levels exhibited poor OS (p = 0.0004). | (207) |
| miR-486-5p | Tissue, ell |
Bioinformatics, qRT-PCR | Down | Diagnosis | AUC = 0.9082 (95% CI: 3.47-1.03; p = 0.0003). | (208) | ||
| miR-1 | Tissue | Bioinformatics | Down | Diagnosis | AUC = 0.9096, with 71% sensitivity and 88% specificity. | (209) | ||
| lncRNA | TTTY16, POU6F2-AS2, CACNA2D3-AS1 | Tissue | Bioinformatics | Up | Prognosis | The AUC value for the three lncRNAs correlated with 3-year survival was 0.629 in LUSC patients. | (210) | |
| LINC02323 | Tissue | Bioinformatics | Up | Prognosis | LUSC patients with high LINC02323 levels exhibited poor OS (p = 0.0089). | (211) | ||
| circRNA | hsa_circ_0014235, hsa_circ_0025580 | qRT-PCR | Up | Diagnosis | The AUC values of hsa_circ_0014235 and hsa_circ_0025580 were 0.8254 and 0.8003 in LUSC patients, respectively. | (212) | ||