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. 2023 Sep 22;22:156. doi: 10.1186/s12944-023-01891-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Sirt6 regulates foam cell lipolysis through increased lipophagic flux. A–N Immunoblots and quantitative analyses of the expression of LC3b, LAMPI, Beclin1, p62, PLIN2 and adipophilin; data are expressed as mean ± SEM (One way ANOVA showed that there was statistical significance among groups. ^*P < 0.05 versus the C57BL/6J group; ^#P < 0.05 vs the ApoE^−/− group; ^&P < 0.05 vs the ApoE^−/−:Sirt6^−/− group [n = 10]). O–Q Results from immunoblotting and quantitative studies of LC3 and p62 in cultured macrophages without or with bafilomycin A1; data are expressed as mean ± SEM (One way ANOVA showed that there was statistical significance among groups. ^*P < 0.05 vs the control group; ^#P < 0.05 vs the Ac-LDL group; ^&P < 0.05 vs the Ac-LDL + Ad-sh-Sirt6 group; ^$P < 0.05 vs the Ad-sh-Sirt6 group; ^ŦP < 0.05 vs the control + bafilomycin A1 group; ^ǂP < 0.05 vs the Ac-LDL + Ad-sh-Sirt6 + bafilomycin A1 group; ^ФP < 0.05 vs the Ac-LDL + Ad-Sirt6 + bafilomycin A1 group). R–T LC3 and p62 levels in cultured macrophages without and with bafilomycin A1 were analyzed by immunoblotting and quantitative analysis (One way ANOVA showed that there was statistical significance among groups. ^*P < 0.05 vs the control group; ^#P < 0.05 vs the Ac-LDL group; ^&P < 0.05 vs the Ac-LDL + Ad-Sirt6 group; ^$P < 0.05 vs the Ad-Sirt6 group; ^ŦP < 0.05 vs the control + bafilomycin A1 group; ^ǂP < 0.05 vs the Ac-LDL + Ad-Sirt6 + bafilomycin A1 group; ^ФP < 0.05 vs the Ac-LDL + Ad-Sirt6 + bafilomycin A1 group [n = 6 separate experiments])