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. 2023 Sep 22;22:156. doi: 10.1186/s12944-023-01891-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Overexpression of Sirt6 results in enhanced plaque stability. A Immunohistochemical analysis of macrophages (CD68) and α-smooth muscle actin (SMA); Collagen was stained using Masson’s reagent, and the lipid vacuole was stained with Oil red O. B–C Examining CD68 positive area and the plaque stabilisation score quantitatively. Data are presented as mean ± SE (One way ANOVA showed that there was statistical significance among groups, ^*P < 0.05 vs ApoE^−/− mice [n = 10]; ^#P < 0.05 vs ApoE^−/−: Sirt6^−/− mice [n = 10]). D Plaque slices were immunostained with a fluorescent anti-MMP2 antibody. E A quantitative study of the plaque area that showed positive staining for MMP2; data are presented as mean ± SE (One way ANOVA showed that there was statistical significance among groups, ^*P < 0.05 vs ApoE^−/− mice [n = 10]; ^#P < 0.05 vs ApoE^−/−: Sirt6Tg [n = 10])