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. 2023 Sep 8;11:1234340. doi: 10.3389/fbioe.2023.1234340

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Copyright © 2023 Vyas, Shah, Singh and Prajapati.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Laryngotracheal reconstruction scaffold design. Perspective view of the laryngotracheal reconstruction computer-aided design with multiple channels shown to allow for cellular incubation and growth (I). Photographs of typical graft during and after in vivo placement in rabbit (Simonen et al., 2023): intraoperative view, (II _B ) bronchoscopic view at 4 weeks, (C) ex vivo rabbit trachea with graft at 4 weeks. Arrows indicate the location of the graft (II _A , II _C ) and the lumen of the trachea without granulation tissue or scarring (B). In vivo histology: (III _A ) de novo cartilage formation at 8 weeks and (III _B ) neocartilage formed at 12 weeks. The original polylactic acid construct is still present (arrows). ×100 original magnification. Safranin O/fast green. Reproduce with permission from (Rehmani et al., 2017) under Creative Commons Attribution-Non-Commercial 4.0 License.